Research indicates that leptin, a hormone released by fat cells to regulate appetite, could reduce the effects of toxic brain proteins. These proteins cause plaques and tangles in the brain, leading to memory loss and Alzheimer's disease. So, what does the new research say about the link between leptin and Alzheimer's?
And, what does this mean for the future of dementia care?
Abnormal Brain Proteins Contribute to Dementia
In types of dementia like Alzheimer's disease, dysfunctional amyloid and tau proteins found in our brain can clump together, causing build-ups of plaques and tangles. The abnormal function of these proteins can be very dangerous, killing brain cells and directly damaging blood vessels. This can ultimately worsen dementia symptoms.
While a cure for Alzheimer's remains elusive, researchers are closer than ever to understanding how we might stop Alzheimer's in its tracks
Leptin and Alzheimer's: A Promising Link
Researchers at the University of Dundee found that a part of leptin can prevent amyloid and tau from disrupting brain synapses. This could make leptin a key player in stopping Alzheimer's in its earliest stages.
Professor Jenni Harvey, leading the research, noted that leptin could significantly slow or even stop the disease. The study identified six amino acid fragments within leptin that block amyloid and tau's negative effects, enabling the design of a potential drug template.
While research into leptin is ongoing, there are already steps you can take to support healthy brain function.
How can I support healthy Tau and Amyloid levels naturally?
Amyloid and tau proteins have important functions within the body, but accumulations of these proteins can be dangerous. To help avoid the toxic build-ups, it's a good idea to pursue a healthy lifestyle.
Top Lifestyle Tips:
✅ Maintain a healthy diet that supports cognitive function. For helpful advice, see our guide on: Food That Feeds Your Brain
✅ Exercise consistently with Simple Exercises You Can Do At Home
✅ Keep your brain active by learning new things.
Did you know staying social is great for your brain health? Discover: Easy ways seniors can stay socially active
✅Reduce stress, and optimise your sleep
While there is currently no cure for Alzheimer's, maintaining a healthy lifestyle can reduce your risk and help alleviate dementia symptoms.
The Future of Leptin in Dementia Care
While it may take years for leptin-based drugs to become available, this discovery is promising. Currently, 900,000 people in the UK live with dementia, a number expected to rise to 1.6 million by 2050. Alzheimer’s is the most common form, and currently, there is no treatment that can reverse the brain damage it causes.
Common symptoms of mild cognitive impairment (MCI), a precursor to dementia, include memory problems like misplacing items or forgetting recent conversations. About 20% of people over 65 have MCI, and 10% of them may develop dementia.
